Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 7/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8847658 | 0.99 | AGTR1 (0.47) | AGTR1AGTR2PPARGKDM4EALDH1A1 | |
| SCHEMBL8848293 | 0.98 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL8848196 | 0.97 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL7309046 | 0.91 | AGTR1 (0.58) | AGTR1AGTR2PPARG | |
| SCHEMBL7302801 | 0.91 | LMNA (0.43) | AGTR1AGTR2PPARGKDM4EALDH1A1 | |
| SCHEMBL7310637 | 0.91 | AGTR1 (0.57) | AGTR1AGTR2PPARG | |
| SCHEMBL7306067 | 0.90 | LMNA (0.42) | AGTR1AGTR2PPARGKDM4EALDH1A1 | |
| SCHEMBL8847656 | 0.89 | AGTR1 (0.47) | AGTR1AGTR2PPARGKDM4EALDH1A1 | |
| SCHEMBL8394561 | 0.89 | ACHE (0.49) | AGTR1AGTR2PPARG | |
| SCHEMBL7309295 | 0.89 | AGTR1 (0.42) | AGTR1AGTR2PPARGKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |