Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.57 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.57 |
| ▸ | XDH | P47989 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848018 | 1.00 | GABBR2 (0.57) | GABBR2GABBR1XDHMMP2ALDH1A1 | |
| SCHEMBL8848334 | 0.82 | XDH (0.46) | GABBR2GABBR1XDHALDH1A1KDM4E | |
| SCHEMBL5849926 | 0.81 | XDH (0.63) | GABBR2GABBR1XDHMMP2ALDH1A1 | |
| SCHEMBL21996031 | 0.74 | XDH (0.46) | GABBR2GABBR1XDHALDH1A1KDM4E | |
| SCHEMBL30799215 | 0.74 | XDH (0.46) | GABBR2GABBR1XDHALDH1A1KDM4E | |
| SCHEMBL16610343 | 0.73 | PELI1 (0.46) | GABBR2GABBR1MMP2ALDH1A1KDM4E | |
| SCHEMBL28818999 | 0.73 | PELI1 (0.46) | GABBR2GABBR1MMP2ALDH1A1KDM4E | |
| SCHEMBL16610382 | 0.73 | GABBR2 (0.40) | GABBR2GABBR1APPALOX5ERN1 | |
| SCHEMBL14281153 | 0.73 | XDH (0.53) | GABBR2GABBR1XDHMMP2ALDH1A1 | |
| SCHEMBL9228329 | 0.73 | GABBR2 (1.00) | GABBR2GABBR1ALDH1A1MAPTALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444899-B1 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION YHTYMAE OY (FI) | 1997-02-05 | — | — | EP | claimed |
| EP-0444899-A2 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION-YHTYMÀ OY (FI) | 1991-09-04 | — | — | EP | claimed |
| EP-0444899-B1 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION YHTYMAE OY (FI) | 1997-02-05 | — | — | EP | disclosed |
| US-5489614-A | MEDICINAL ANTIOXIDANTS USED IN PREVENTION AND TREATMENT OF TISSUE DAMAGE INDUCED BY LIPID PEROXIDATION | ORION-YHTYMA OY (FI) | 1996-02-06 | — | — | US | disclosed |
| EP-0444899-A2 | Catechol derivatives, their physiologically acceptable salts, esters and their use in the treatment of tissue damage induced by lipid peroxidation | ORION-YHTYMÀ OY (FI) | 1991-09-04 | — | — | EP | disclosed |