SCHEMBL8848347

SCHEMBL8848347

CCCCCCc1cc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)cc1OCC(O)COc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PLA2G4B P0C869 1/20 0.38
SLC2A1 P11166 1/20 0.36
TP53 P04637 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
ABCB1 P08183 1/20 0.34
ADRB2 P07550 4/20 0.33
ADRB1 P08588 4/20 0.33
TSHR P16473 3/20 0.33
LMNA P02545 2/20 0.33
S1PR1 P21453 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CNR2 P34972 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8848044 0.88 CNR2 (0.37) PLA2G4BTP53SMN1; SMN2CNR2
SCHEMBL8848384 0.88 CNR2 (0.35) PLA2G4BTP53SMN1; SMN2TSHRCNR2
SCHEMBL8848129 0.84 ESR1 (0.39) TP53SMN1; SMN2CNR2
SCHEMBL8848576 0.79 MAPT (0.44) TP53SMN1; SMN2TSHRLMNACYP1A2
SCHEMBL9011638 0.79 NR1H4 (0.37) TP53SMN1; SMN2CNR2
SCHEMBL8848324 0.79 PLA2G4B (0.38) PLA2G4BSMN1; SMN2ADRB2ADRB1TSHR
SCHEMBL8848709 0.79 CNR2 (0.38) PLA2G4BSMN1; SMN2ADRB2ADRB1CNR2
SCHEMBL8848297 0.79 PLA2G4B (0.38) PLA2G4BSMN1; SMN2ADRB2ADRB1TSHR
SCHEMBL8855632 0.78 MAPT (0.36) PLA2G4BSMN1; SMN2TSHRCNR2
SCHEMBL6849930 0.78 PLA2G4B (0.34) PLA2G4BSMN1; SMN2ABCB1LMNACNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0704437-A2 Red-shifted tris-aryl-s-triazines and compositions stabilized therewith CIBA-GEIGY AG (CH) 1996-04-03 EP claimed
US-5648488-A Compositions stabilized with red-shifted tris-aryl-s-triazines CIBA-GEIGY CORPORATION (US) 1997-07-15 US disclosed
US-5637706-A ACTINIC RADIATION STABILIZERS CIBA-GEIGY CORPORATION (US) 1997-06-10 US disclosed
US-5556973-A Red-shifted tris-aryl-s-triazines and compositions stabilized therewith CIBA-GEIGY CORPORATION (US) 1996-09-17 US disclosed
US-5543518-A ALKYLATION OF TRIS-ARYL-S-TRIAZINE COMPOUNDS WITH ALKENES, CYCLOALKENES, PHENYLALKENES CIBA-GEIGY CORPORATION (US) 1996-08-06 US disclosed