Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437039 | 0.89 | USP2 (0.36) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL8847549 | 0.87 | CETP (0.36) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL8848087 | 0.85 | CETP (0.37) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL11937857 | 0.82 | ALDH1A1 (0.59) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL16312791 | 0.79 | CYP1A2 (0.55) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL8660271 | 0.78 | TSHR (0.37) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL202959 | 0.75 | USP2 (0.31) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL487371 | 0.75 | USP2 (0.31) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL8847928 | 0.74 | CYP1A2 (0.37) | LMNACYP1A2USP2ALDH1A1TSHR | |
| SCHEMBL487300 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614519-A | (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists | KARL THOMAE GMBH (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5602127-A | ADMINISTERING TO TREAT HYPERTENSION | KARL THOMAE GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5594003-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-14 | — | — | US | disclosed |
| US-5591762-A | HYPOTENSIVE AGENTS | DR. KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |