SCHEMBL8848746

SCHEMBL8848746

Cc1ccc(COC(=O)N=NC(=O)OCc2ccc(C)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.47
MMP12 P39900 2/20 0.47
MMP1 P03956 1/20 0.47
MMP9 P14780 1/20 0.47
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
AGXT P21549 2/20 0.47
MAOB P27338 1/20 0.46
P2RX4 Q99571 1/20 0.45
PARP10 Q53GL7 1/20 0.45
NAAA Q02083 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
ALDH1A1 P00352 3/20 0.43
MAPT P10636 3/20 0.43
GAA P10253 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8848742 1.00 MMP2 (0.47) MMP2MMP12MMP1MMP9NPC1
SCHEMBL260054 0.94 MMP2 (0.44) MMP2MMP12MMP1MMP9NPC1
SCHEMBL16690021 0.93 MMP2 (0.43) MMP2MMP12MMP1MMP9NPC1
SCHEMBL12090443 0.93 MAOB (0.45) MMP2MMP12MMP1MMP9NPC1
SCHEMBL16690020 0.93 MMP2 (0.43) MMP2MMP12MMP1MMP9NPC1
SCHEMBL15844217 0.82 ALDH1A1 (0.47) NPC1RAB9AMAOBALDH1A1MAPT
SCHEMBL15844218 0.82 ALDH1A1 (0.47) NPC1RAB9AMAOBALDH1A1MAPT
SCHEMBL6646548 0.81 AGXT (0.52) MMP2MMP12MMP1MMP9NPC1
SCHEMBL26555 0.81 AGXT (0.52) MMP2MMP12MMP1MMP9NPC1
SCHEMBL2299547 0.80 NAAA (0.49) MMP2MMP12MMP1MMP9NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0581618-B1 Rubber composition and production thereof SUMITOMO CHEMICAL CO (JP) 1997-06-18 EP disclosed
US-5362794-A Butadiene-styrene rubber, azodocarboxylic ester; automobile tires SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1994-11-08 US disclosed
EP-0581618-A1 Rubber composition and production thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-02-02 EP disclosed