Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 10/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8848806 | 0.86 | KDM4E (0.42) | GRK6ELANEMAPTLMNAALDH1A1 | |
| SCHEMBL8848542 | 0.80 | ELANE (0.51) | ELANECA2 | |
| SCHEMBL8848848 | 0.78 | ELANE (0.40) | GRK6ELANEMAPTCYP3A4CA2 | |
| SCHEMBL6608296 | 0.78 | GRK6 (0.45) | GRK6MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL8848538 | 0.75 | ELANE (0.48) | ELANEMAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL22641752 | 0.74 | HSD17B1 (0.42) | ELANEMAPTLMNAALDH1A1CYP3A4 | |
| SCHEMBL5822962 | 0.72 | NOTUM (0.41) | MAPTALDH1A1 | |
| SCHEMBL19317257 | 0.72 | CYP1A2 (0.33) | — | |
| SCHEMBL6611955 | 0.71 | FGFR1 (0.46) | CYP3A4AR | |
| SCHEMBL2967259 | 0.71 | VDR (0.67) | AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602161-A | ELASTASE INHIBITORS; PREVENTING AND TREATING EMPHYSEMA, ENDOTOXIN-INDUCED LUNG DISORDERS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-11 | — | — | US | disclosed |
| EP-0676396-A1 | Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1995-10-11 | — | — | EP | disclosed |