Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29677278 | 0.84 | LMNA (0.64) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL19478438 | 0.84 | LMNA (0.64) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL7038965 | 0.84 | LMNA (0.64) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL12508055 | 0.80 | LMNA (0.59) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL14406408 | 0.80 | KMT2A (0.64) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL25198969 | 0.80 | LMNA (0.62) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL29522421 | 0.80 | LMNA (1.00) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL25204645 | 0.78 | ALDH1A1 (0.74) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL6567228 | 0.78 | ALDH1A1 (0.65) | LMNAKMT2AMEN1NPSR1CYP1A2 | |
| SCHEMBL10001894 | 0.78 | AR (0.41) | LMNAKMT2AMEN1NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527817-B2 | Compounds for treating peripheral; neuropathies and other neurodegenerative; disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527817-B2 | Compounds for treating peripheral; neuropathies and other neurodegenerative; disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-12-27 | — | — | US | disclosed |
| US-20140303203-A1 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |
| US-20140303203-A1 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-10-09 | — | — | US | disclosed |
| US-5627192-A | ANTILIPEMIC AGENTS, ANTICHOLESTEROL AGENTS OR ANTIOXIDANTS | BRISTROL-MYERS SQUIBB COMPANY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5411969-A | Antihyperlipidemic/antioxidant dihydroquinolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| US-5391765-A | Lowers low density lipoproteins | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140303203-A1 | COMPOUNDS FOR TREATING PERIPHERAL; NEUROPATHIES AND OTHER NEURODEGENERATIVE; DISORDERS | HSP90AB1, HSP90AA1, HSP90AB2P | LMNA 3007/4885KMT2A 4456/4885MEN1 4593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.