Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.65 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1323562 | 0.96 | MAPT (0.70) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL14406408 | 0.84 | KMT2A (0.64) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL25204645 | 0.82 | ALDH1A1 (0.74) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL7044480 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL7044479 | 0.81 | LMNA (0.56) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL8849533 | 0.78 | LMNA (0.66) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL1323561 | 0.78 | LMNA (0.58) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL2190314 | 0.77 | LMNA (0.64) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL19478438 | 0.77 | LMNA (0.64) | ALDH1A1MAPTKDM4EALOX12HTT | |
| SCHEMBL29677278 | 0.77 | LMNA (0.64) | ALDH1A1MAPTKDM4EALOX12HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406628-A1 | TETRAHYDROQUINOLINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003004028-A1 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2003-01-16 | — | — | WO | disclosed |