Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2063939 | 0.80 | KCNA5 (0.63) | LMNAHTTKMT2ARAB9ANPC1 | |
| SCHEMBL27680029 | 0.78 | LMNA (1.00) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL2063289 | 0.72 | KCNA5 (0.63) | ALDH1A1HPGDKCNA5KCNH2MAPK1 | |
| SCHEMBL884680 | 0.71 | KCNA5 (0.61) | KMT2ARAB9ANPC1KCNA5KCNH2 | |
| SCHEMBL29415439 | 0.70 | NPC1 (0.63) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL998521 | 0.70 | NPC1 (0.63) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL14082531 | 0.69 | LMNA (0.80) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL11829949 | 0.69 | LMNA (0.72) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL4969859 | 0.69 | ALDH1A1 (0.59) | LMNAHTTKMT2AALDH1A1RAB9A | |
| SCHEMBL2063683 | 0.69 | ALDH1A1 (0.45) | ALDH1A1RAB9ANPC1KCNA5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940406-A2 | POTASSIUM CHANNEL INHIBITORS | Merck and Co., Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050348-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-05-03 | — | — | WO | claimed |