Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489302 | 0.89 | EPHX2 (0.40) | EPHX2TET2TSHRRECQLMETAP1 | |
| SCHEMBL4450020 | 0.86 | — | — | |
| SCHEMBL8851320 | 0.84 | GAA (0.42) | EPHX2TSHRMETAP1HSD17B10MGAM | |
| Hydrochloric Acid SCHEMBL76321 | 0.84 | EPHX2 (0.47) | EPHX2TET2TSHRRECQLMETAP1 | |
| SCHEMBL7440501 | 0.82 | EPHX2 (0.55) | EPHX2TET2TSHRRECQLKDM4E | |
| SCHEMBL1977433 | 0.82 | EPHX2 (0.59) | EPHX2KDM4EKMT2APOLBNPSR1 | |
| SCHEMBL9233824 | 0.81 | EPHX2 (0.45) | EPHX2TSHRKDM4EKMT2A | |
| SCHEMBL8851815 | 0.81 | PPM1B (0.36) | EPHX2METAP1KDM4EALDH1A1POLB | |
| SCHEMBL2411177 | 0.80 | EPHX2 (0.62) | EPHX2KDM4EALDH1A1KMT2APOLB | |
| SCHEMBL9141301 | 0.80 | METAP1 (0.35) | METAP1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |
| EP-0645390-A1 | Trisubstituted pyrimido 5,4-d pyrimidines for modulating multidrug resistance, drugs containing these compounds and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1995-03-29 | — | — | EP | disclosed |