Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 6/20 | 0.59 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.59 |
| ▸ | GNAI1 | P63096 | 6/20 | 0.59 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851122 | 0.89 | GNAI3 (0.53) | GNAI3GNAO1GNAI1SOS1KCNH2 | |
| SCHEMBL8851373 | 0.88 | GNAI3 (0.62) | GNAI3GNAO1GNAI1SOS1KCNH2 | |
| SCHEMBL15884117 | 0.87 | GNAI3 (0.40) | GNAI3GNAO1GNAI1LMNAKMT2A | |
| SCHEMBL12951516 | 0.83 | KMT2A (0.44) | GNAI3GNAO1GNAI1LMNAKMT2A | |
| SCHEMBL8851721 | 0.81 | GNAI3 (0.58) | GNAI3GNAO1GNAI1SOS1KCNH2 | |
| SCHEMBL9452575 | 0.81 | KMT2A (0.50) | GNAI3GNAO1GNAI1LMNAKMT2A | |
| SCHEMBL1070277 | 0.79 | GNAI3 (0.81) | GNAI3GNAO1GNAI1SOS1KCNH2 | |
| SCHEMBL8851486 | 0.79 | LMNA (0.35) | GNAI3GNAO1GNAI1LMNAKMT2A | |
| SCHEMBL8682833 | 0.78 | GNAI3 (0.67) | GNAI3GNAO1GNAI1SOS1KCNH2 | |
| SCHEMBL6247785 | 0.78 | GNAI3 (0.73) | GNAI3GNAO1GNAI1SOS1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | disclosed |