Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.48 |
| ▸ | ERN1 | O75460 | 4/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29442952 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1TUBB1 | |
| SCHEMBL8859774 | 0.81 | ERN1 (0.53) | ALDH1A1TUBB1ERN1CYP1A1MAPT | |
| SCHEMBL3751505 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TSHRKDM4ETDP1TUBB1 | |
| SCHEMBL27657142 | 0.80 | ACHE (0.46) | TUBB1CYP1A1CYP3A4MAPTTUBB4A | |
| SCHEMBL3152057 | 0.76 | PRKDC (0.58) | ALDH1A1TSHRKDM4ETDP1TUBB1 | |
| SCHEMBL16093496 | 0.76 | ERN1 (0.62) | ALDH1A1TSHRKDM4ETDP1ERN1 | |
| SCHEMBL16096243 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TSHRKDM4ETDP1TUBB1 | |
| SCHEMBL11761215 | 0.75 | ALDH1A1 (0.45) | ALDH1A1TSHRKDM4ETDP1ERN1 | |
| SCHEMBL21830258 | 0.75 | CYP1A1 (0.41) | ALDH1A1TSHRTDP1CYP1A1CYP3A4 | |
| SCHEMBL2743529 | 0.75 | ALDH1A1 (0.57) | ALDH1A1TSHRKDM4ETDP1TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093228-A1 | METHOD FOR PREPARING ANTHRAQUINONE-FUNCTIONALIZED POLY(VINYLIDENE FLUORIDE) MEMBRANE | XIAMEN UNIVERSITY OF TECHNOLOGY (CN) | 2018-04-05 | — | — | US | claimed |
| CN-105642127-B | A kind of preparation method of anthraquinone functionalization polyvinylidene fluoride (PVDF) ultrafiltration membrane | 厦门理工学院 | 2018-01-05 | — | — | CN | claimed |
| CN-105642127-A | Preparation method of anthraquinone functionalized polyvinylidene fluoride ultrafiltration membrane | 厦门理工学院 | 2016-06-08 | — | — | CN | claimed |
| CN-102617342-B | (+/-)-alkannin naphthazarin parent nucleus oxygen alkyl acylation derivant and preparation method thereof | UNIV SHANGHAI JIAOTONG | 2014-04-30 | — | — | CN | claimed |
| CN-102199080-B | Method for preparing shikonin with high optical purity by asymmetric total synthetic method | UNIV SHANGHAI JIAOTONG | 2013-07-03 | — | — | CN | claimed |
| CN-102617342-A | (+/-)-alkannin naphthazarin parent nucleus oxygen alkyl acylation derivant and preparation method thereof | UNIV SHANGHAI JIAOTONG | 2012-08-01 | — | — | CN | claimed |
| CN-102399139-A | Preparation method of high optical purity shikonin and alkannin, and derivatives thereof | UNIV SHANGHAI JIAOTONG | 2012-04-04 | — | — | CN | claimed |
| CN-1686994-A | Total synthesis method for preparing receme alkannin | UNIV SHANGHAI JIAOTONG (CN) | 2005-10-26 | — | — | CN | claimed |
| JP-59175449-A | — | — | None | — | — | JP | disclosed |
| WO-2025230237-A1 | MANUFACTURING METHOD FOR INTERMEDIATE COMPOUND FOR SHIKONIN SYNTHESIS | 주식회사 그라스메디 | 2025-11-06 | — | — | WO | disclosed |
| US-20230406804-A1 | PROTEIN KINASE INHIBITORS | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | 2023-12-21 | — | — | US | disclosed |
| US-20210355060-A1 | PROTEIN KINASE INHIBITORS | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND | 2021-11-18 | — | — | US | disclosed |
| CN-109384697-A | Sulfur-containing alkannin 9 oxime derivate and application thereof | 上海交通大学 | 2019-02-26 | — | — | CN | disclosed |
| US-20180093228-A1 | METHOD FOR PREPARING ANTHRAQUINONE-FUNCTIONALIZED POLY(VINYLIDENE FLUORIDE) MEMBRANE | XIAMEN UNIVERSITY OF TECHNOLOGY (CN) | 2018-04-05 | — | — | US | disclosed |
| US-5696276-A | Process for preparing 5,8-dihydroxynaphthoquinone derivatives, novel 5,8-dihydroxynaphthoquinone derivatives and their use as anticancer agent | KUHNIL PHARMACEUTICAL CO., LTD. (KR) | 1997-12-09 | — | — | US | disclosed |
| EP-0402487-B1 | PRODUCTION OF BLACKING MATERIAL AND APPLICATION THEREOF | IHARA CHEMICAL IND CO (JP) | 1994-04-06 | — | — | EP | disclosed |
| US-5244469-A | Process for preparation of black coloring materials and application thereof: chitosan treated with black extract of lithospermum root | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-09-14 | — | — | US | disclosed |
| EP-0402487-A1 | PRODUCTION OF BLACKING MATERIAL AND APPLICATION THEREOF | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1990-12-19 | — | — | EP | disclosed |
| US-4560511-A | Method of producing shikonin | KYUSHU INSTITUTE OF TECHNOLOGY (JP) | 1985-12-24 | — | — | US | disclosed |
| JP-S59175449-A | PRODUCTION OF SHIKONIN | KYUSHU KOGYO DAIGAKU | 1984-10-04 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406804-A1 | PROTEIN KINASE INHIBITORS | ERBB2, ERBB3, MAP3K20 | ALDH1A1 4558/4885TSHR 1434/4885KDM4E 1222/4885 |
| US-20210355060-A1 | PROTEIN KINASE INHIBITORS | ERBB2, ERBB3, MAP3K20 | ALDH1A1 4558/4885TSHR 1434/4885KDM4E 1222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.