Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8851209 | 0.93 | LMNA (0.41) | PIK3CDLMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL9235182 | 0.93 | LMNA (0.41) | PIK3CDLMNAKDM4EHPGDALDH1A1 | |
| Oxalic Acid SCHEMBL9235915 | 0.89 | LMNA (0.44) | PIK3CDLMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL8852171 | 0.88 | PIK3CD (0.42) | PIK3CDEGFRKDM4EHPGDALDH1A1 | |
| SCHEMBL8851316 | 0.81 | PIK3CD (0.36) | PIK3CDMTOR | |
| SCHEMBL9229772 | 0.81 | PIK3CD (0.42) | PIK3CDKDM4EHPGDALDH1A1GLA | |
| SCHEMBL8851821 | 0.80 | PIK3CD (0.35) | PIK3CDMEN1KMT2AMTORMAPK1 | |
| SCHEMBL8851157 | 0.80 | PDE10A (0.41) | LMNAHTTMAPTNPSR1MTOR | |
| SCHEMBL8852164 | 0.78 | PIK3CD (0.42) | PIK3CDEGFRKDM4EHPGDALDH1A1 | |
| SCHEMBL8852150 | 0.78 | MTOR (0.39) | PIK3CDKDM4EALDH1A1MAPTMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618814-A | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds | DR. KARL THOMAE GMBH (DE) | 1997-04-08 | — | — | US | claimed |