SCHEMBL8853709

SCHEMBL8853709

S=C1CCSc2ccccc2N1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.67
ALOX12 P18054 2/20 0.50
HPGD P15428 2/20 0.50
MEN1 O00255 6/20 0.49
KMT2A Q03164 6/20 0.49
GAA P10253 5/20 0.48
MAPT P10636 5/20 0.43
NOX1 Q9Y5S8 2/20 0.43
CYP1A2 P05177 1/20 0.43
BCHE P06276 1/20 0.43
POLB P06746 1/20 0.43
CYP3A4 P08684 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
ALOX15 P16050 1/20 0.43
MAOA P21397 1/20 0.43
CNR1 P21554 1/20 0.43
ACHE P22303 1/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
HTR2C P28335 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9628788 0.89 ALDH1A1 (0.62) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL88687 0.80 ALDH1A1 (1.00) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL1756087 0.77 HDAC1 (0.51) ALDH1A1ALOX12MEN1KMT2AGAA
SCHEMBL9171036 0.70 ALDH1A1 (0.58) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL9628996 0.70 MAPT (0.53) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL8853378 0.69 ALDH1A1 (0.56) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL3556450 0.67 GAA (0.96) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL88725 0.67 MEN1 (0.65) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL88911 0.67 GAA (0.96) ALDH1A1ALOX12HPGDMEN1KMT2A
SCHEMBL29364653 0.67 GAA (0.96) ALDH1A1ALOX12HPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0657407-B1 Process for the preparation of 3-fluoro-4,6-dichlorotoluene BAYER AG (DE) 1997-12-10 EP disclosed
US-5475164-A Process for preparing 3-fluoro-4,6-dichlorotoluene BAYER AKTIENGESELLSCHAFT (DE) 1995-12-12 US disclosed
EP-0657407-A1 Process for the preparation of 3-fluoro-4,6-dichlorotoluene BAYER AG (DE) 1995-06-14 EP disclosed
EP-0442115-B1 Process for nucleus-chlorination of aromatic hydrocarbons BAYER AG (DE) 1993-11-24 EP disclosed
US-5105036-A Friedel-Crafts catalyst and oxy-substituted cyclic amidines as cocatylsts; preferential formation of p-isomer BAYER AKTIENGESELLSCHAFT (DE) 1992-04-14 US disclosed
EP-0442115-A1 Process for nucleus-chlorination of aromatic hydrocarbons BAYER AG (DE) 1991-08-21 EP disclosed
EP-0292824-B1 PROCESS FOR THE NUCLEAR CHLORINATION OF AROMATIC HYDROCARBONS BAYER AG (DE) 1990-08-01 EP disclosed
US-4851596-A Process for nucleus-chlorination of aromatic hydrocarbons BAYER AKTIENGESELLSCHAFT (DE) 1989-07-25 US disclosed
EP-0292824-A1 Process for the nuclear chlorination of aromatic hydrocarbons BAYER AG (DE) 1988-11-30 EP disclosed