Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dienestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 9/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroquinone SCHEMBL4804304 | 0.84 | ESR1 (0.44) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL8854079 | 0.81 | ESR1 (0.71) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL2896848 | 0.78 | ESR1 (1.00) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL52170 | 0.78 | ESR1 (1.00) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL2896853 | 0.78 | ESR1 (1.00) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL8425094 | 0.76 | ESR1 (0.85) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL6573104 | 0.76 | ESR1 (0.85) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL9317394 | 0.76 | ESR1 (0.94) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| SCHEMBL7924649 | 0.76 | ALOX15 (0.52) | ESR1LMNACYP3A4HSD17B10MEN1 | |
| Dienestrol SCHEMBL114016 | 0.74 | ESR1 (0.81) | ESR1LMNACYP3A4HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638975-A2 | METHOD FOR PREPARING OXYCODONE | Boehringer Ingelheim Chemicals, Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6469170-B1 | PRODUCING A DIENOL ORGANOSILYL ETHER AT POSITION 6 OF THE C-RING OF CODEINONE THEREBY FORMING DIENOL ORGANOSILYL ETHER CONGENER OF CODEINONE; OXIDIZING DIENOL ORGANOSILYL ETHER TO FORM 14-HYDROXYCODEINONE; HYDROGENATING TO PRODUCE OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2002-10-22 | — | — | US | disclosed |
| US-20020143183-A1 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2002-10-03 | — | — | US | disclosed |
| US-6403798-B2 | PRODUCING A DIENOL ORGANOSILYL ETHER AT POSITION 6 OF THE C-RING OF CODEINONE THEREBY FORMING A DIENOL ORGANOSILYL ETHER CONGENER OF CODEINONE, OXIDIZING THE INTERMEDIATE TO FORM 14-HYDROXYCODEINONE, AND HYDROGENATING UNSATURATION | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2002-06-11 | — | — | US | disclosed |
| US-6262266-B1 | REACTING MORPHINAN-6-ONE COMPOUND WITH ORGANOSILYL COMPOUND IN PRESENCE OF STRONG AMINE BASE AND APROTIC SOLVENT | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2001-07-17 | — | — | US | disclosed |
| US-20010005754-A1 | Method for preparing oxycodone | CHIU FANG-TING (US) | 2001-06-28 | — | — | US | disclosed |
| WO-2001029047-A2 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001029048-A2 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| US-6177567-B1 | FORMATION OF AN DIENOLSILYL ETHER CONGENER OF CODEINONE; OXIDATION OF THE DIENOLSILYL ETHER CONGENER AND HYDROGENATION OF THE RESULTING 14-HYDROXYCODEINONE PRODUCT. | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2001-01-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010005754-A1 | Method for preparing oxycodone | OPRK1, OPRM1, OPRD1 | ESR1 3016/4885LMNA 3531/4885CYP3A4 56/4885 |
| US-20020143183-A1 | METHOD FOR PREPARING OXYCODONE | OPRK1, OPRM1, OPRD1 | ESR1 3016/4885LMNA 3531/4885CYP3A4 56/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.