SCHEMBL8854099

SCHEMBL8854099

Cc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.44
OPRM1 P35372 1/20 0.42
OPRD1 P41143 1/20 0.42
TP53 P04637 1/20 0.41
TYMP P19971 1/20 0.41
SHBG P04278 1/20 0.40
KDM4E B2RXH2 4/20 0.39
GAA P10253 4/20 0.39
POLB P06746 3/20 0.39
HTT P42858 2/20 0.39
JAK2 O60674 1/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
MAPK1 P28482 1/20 0.39
MPI P34949 1/20 0.39
BLM P54132 1/20 0.39
MCL1 Q07820 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
IDH1 O75874 1/20 0.39
NR1H2 P55055 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8854091 0.89 CALM1 (0.46) CALM1OPRM1OPRD1TP53TYMP
SCHEMBL11521959 0.84 CALM1 (0.55) CALM1OPRM1OPRD1TP53TYMP
SCHEMBL11523704 0.82 CALM1 (0.58) CALM1OPRM1OPRD1TP53TYMP
SCHEMBL10870265 0.80 KDM4E (0.43) CALM1OPRM1OPRD1SHBGKDM4E
SCHEMBL27922695 0.77 SIRT1 (0.42) CALM1OPRM1OPRD1TYMPKDM4E
SCHEMBL28313729 0.77 CALM1 (0.58) CALM1TP53SHBGKDM4EGAA
SCHEMBL9190942 0.75 CALM1 (0.55) CALM1TP53SHBGKDM4EGAA
SCHEMBL1550879 0.74 ALOX5 (0.46) SHBGKDM4EGAAPOLBHTT
SCHEMBL10923606 0.72 CALM1 (0.41) CALM1OPRM1OPRD1TYMPMAPK1
SCHEMBL16933813 0.72 IDH1 (0.44) CALM1OPRM1OPRD1TYMPIDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5601755-A LIQUID MIXTURES WITH BENZYLTOLUENES, BENZYLXYLENES AND THEIR METHYL DERIVATIVES HAVING HIGH BREAKDOWN VOLTAGE ATOCHEM (FR) 1997-02-11 US claimed
US-5545355-A VOLTAGE TRANSFORMERS, CAPACITORS ATOCHEM (FR) 1996-08-13 US claimed
US-5601755-A LIQUID MIXTURES WITH BENZYLTOLUENES, BENZYLXYLENES AND THEIR METHYL DERIVATIVES HAVING HIGH BREAKDOWN VOLTAGE ATOCHEM (FR) 1997-02-11 US disclosed
US-5545355-A VOLTAGE TRANSFORMERS, CAPACITORS ATOCHEM (FR) 1996-08-13 US disclosed
CN-1028516-C Composition based of methylating and benzylating derivatives of diphenylmethane and application as dielectric ATOCHEM (FR) 1995-05-24 CN disclosed
EP-0444989-B1 Dielectric compositions comprising benzyltoluene and (methylbenzyl)xylene ATOCHEM ELF SA (FR) 1994-09-14 EP disclosed
EP-0446086-B1 Composition comprising methyl and benzyl derivatives of diphenylmethane and its use as dielectricum ATOCHEM ELF SA (FR) 1993-12-08 EP disclosed
US-5220109-A Contacting with excess alkali metal alcoholate, heating, suspending, distillation ATOCHEM (FR) 1993-06-15 US disclosed
EP-0306398-B1 CHEMICAL PROCESS FOR THE DESTRUCTION OF HALOGENATED ORGANIC PRODUCTS ELF ATOCHEM S.A. (FR) 1993-02-03 EP disclosed
CN-1016142-B CHEMICAL PROCESS FOR DESTROYING HALOGENATED ORGANIC PRODUCTS ATOCHEM (FR) 1992-04-08 CN disclosed
EP-0446086-A1 Composition comprising methyl and benzyl derivatives of diphenylmethane and its use as dielectricum ELF ATOCHEM S.A. (FR) 1991-09-11 EP disclosed
CN-1054415-A With ditan methylate and the benzyl derivative is the composition of main component and as dielectric application ATOCHEM (FR) 1991-09-11 CN disclosed
EP-0444989-A1 Dielectric compositions comprising benzyltoluene and (methylbenzyl)xylene ELF ATOCHEM S.A. (FR) 1991-09-04 EP disclosed
CN-1032109-A The chemical process for destroying of halogenated organic products ATOCHEM (FR) 1989-04-05 CN disclosed
EP-0306398-A1 Chemical process for the destruction of halogenated organic products ELF ATOCHEM S.A. (FR) 1989-03-08 EP disclosed
EP-0070218-B1 HALOGENATED AROMATIC COMPOUNDS SUITABLE AS FIRE RETARDERS ELF ATOCHEM S.A. (FR) 1985-06-19 EP disclosed
EP-0088650-A1 Application of chlorinated benzyl toluene and benzyl xylene to lubrication ELF ATOCHEM S.A. (FR) 1983-09-14 EP disclosed
EP-0070218-A1 Halogenated aromatic compounds suitable as fire retarders ELF ATOCHEM S.A. (FR) 1983-01-19 EP disclosed