Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 8/20 | 0.32 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | MMP3 | P08254 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856287 | 0.90 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2TRPV1ALOX5PPARG | |
| SCHEMBL8856352 | 0.88 | TRPV1 (0.35) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856179 | 0.86 | TRPV1 (0.36) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856084 | 0.81 | TRPV1 (0.38) | TRPV1PDE6DALOX5PKML3MBTL1 | |
| SCHEMBL8856354 | 0.80 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856712 | 0.80 | TLR8 (0.39) | ALDH1A1SMN1; SMN2TRPV1L3MBTL1HTT | |
| SCHEMBL8856361 | 0.80 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856091 | 0.80 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856302 | 0.78 | KMT2A (0.38) | ALDH1A1SMN1; SMN2TRPV1ALOX5L3MBTL1 | |
| SCHEMBL8856088 | 0.78 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2TRPV1ALOX5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1991004027-A1 | NEW N-ARYL AND N-HETEROARYLAMIDE AND UREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A: CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1991-04-04 | — | — | WO | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |