Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856361 | 0.85 | TRPV1 (0.37) | KMT2AMEN1TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8856354 | 0.85 | TRPV1 (0.37) | POLBTRPV1ALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8856712 | 0.85 | TLR8 (0.39) | KMT2AMEN1TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8856179 | 0.83 | TRPV1 (0.36) | TRPV1ALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL8856274 | 0.81 | KMT2A (0.46) | KMT2AMEN1TRPV1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8856352 | 0.81 | TRPV1 (0.35) | TRPV1ALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL8856096 | 0.79 | TRPV1 (0.42) | KMT2APOLBMEN1TRPV1ALDH1A1 | |
| SCHEMBL8856091 | 0.79 | ALDH1A1 (0.33) | TRPV1ALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL8856308 | 0.78 | ALOX5 (0.40) | KMT2APOLBMEN1TRPV1PTGES | |
| SCHEMBL8856078 | 0.78 | ALDH1A1 (0.36) | TRPV1ALDH1A1SMN1; SMN2L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1991004027-A1 | NEW N-ARYL AND N-HETEROARYLAMIDE AND UREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A: CHOLESTEROL ACYL TRANSFERASE (ACAT) | PFIZER INC. (US) | 1991-04-04 | — | — | WO | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |