Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856179 | 0.85 | TRPV1 (0.36) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL8856352 | 0.83 | TRPV1 (0.35) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL9431040 | 0.82 | ALOX5 (0.37) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL8856361 | 0.80 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2ALOX5TRPV1PPARG | |
| SCHEMBL8856078 | 0.80 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2ALOX5TRPV1PPARG | |
| SCHEMBL8856302 | 0.79 | KMT2A (0.38) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL8856354 | 0.78 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL8856712 | 0.78 | TLR8 (0.39) | ALDH1A1SMN1; SMN2TRPV1L3MBTL1HTT | |
| SCHEMBL8856287 | 0.78 | TRPV1 (0.37) | ALDH1A1SMN1; SMN2ALOX5PTGESTRPV1 | |
| SCHEMBL8856274 | 0.77 | KMT2A (0.46) | ALDH1A1SMN1; SMN2ALOX5TRPV1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |