Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.34 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856130 | 0.87 | SOAT1 (0.49) | SOAT1PAK1DEGS1HPGDRAB9A | |
| SCHEMBL8856090 | 0.83 | SOAT1 (0.46) | SOAT1DEGS1RAB9ACETPNPC1 | |
| SCHEMBL8325263 | 0.77 | SOAT1 (0.42) | SOAT1ALDH1A1L3MBTL1 | |
| SCHEMBL8856395 | 0.73 | CES2 (0.42) | PAK1ALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL8856174 | 0.70 | SOAT1 (0.47) | SOAT1DEGS1HPGDRAB9ACETP | |
| SCHEMBL8856160 | 0.70 | DEGS1 (0.48) | SOAT1DEGS1ALDH1A1HPGDRAB9A | |
| SCHEMBL8856202 | 0.70 | DEGS1 (0.48) | SOAT1DEGS1ALDH1A1HPGDRAB9A | |
| SCHEMBL8323664 | 0.67 | SOAT1 (0.43) | SOAT1ALDH1A1HPGDCETPL3MBTL1 | |
| SCHEMBL282145 | 0.65 | SOAT1 (1.00) | SOAT1 | |
| SCHEMBL28696320 | 0.64 | CYP1A2 (0.58) | SOAT1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |