SCHEMBL282145

SCHEMBL282145

CCCCCCCCCCCCCCCC(=S)Nc1c(C(C)C)cccc1C(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SOAT1 P35610 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10699124 0.82 SOAT1 (0.69) SOAT1
SCHEMBL9800926 0.79 SOAT1 (0.66) SOAT1
SCHEMBL9317529 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9316540 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9316620 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9315973 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9316503 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9317566 0.78 SOAT1 (0.64) SOAT1
SCHEMBL9048460 0.75 SOAT1 (0.60) SOAT1
SCHEMBL28932540 0.75 SOAT1 (0.59) SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2453926-A2 PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE The Regents of the University of California (US) 2012-05-23 EP claimed
WO-2011008996-A2 PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-20 WO claimed
WO-2010056910-A2 METHODS OF TREATING CARDIOVASCULAR DISORDERS CAROLUS THERAPEUTICS, INC. (US) 2010-05-20 WO claimed
US-20050192245-A1 Medicinal composition for treating arteriosclerosis SANKYO COMPANY, LIMITED (JP) 2005-09-01 US claimed
EP-1555032-A1 MEDICINAL COMPOSITION FOR TREATING ARTERIOSCLEROSIS Sankyo Company, Limited (JP) 2005-07-20 EP claimed
US-20230279048-A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION 2023-09-07 US disclosed
US-11518782-B2 Compositions containing HC-HA/PTX3 complexes and methods of use thereof TISSUETECH, INC. (US) 2022-12-06 US disclosed
EP-3838293-A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF Tissuetech, Inc. (US) 2021-06-23 EP disclosed
US-10925885-B2 Thyromimetics for the treatment of fatty liver diseases METABASIS THERAPEUTICS, INC. (US) 2021-02-23 US disclosed
EP-2872181-B1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF TISSUETECH INC (US) 2020-11-18 EP disclosed
US-20200308219-A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION 2020-10-01 US disclosed
US-10717763-B2 Compositions containing HC-HA/PTX3 complexes and methods of use thereof TISSUETECH, INC. (US) 2020-07-21 US disclosed
US-20060046980-A1 Novel phosphorus-containing thyromimetics METABASIS THERAPEUTICS, INC. 2006-03-02 US disclosed
US-20050192245-A1 Medicinal composition for treating arteriosclerosis SANKYO COMPANY, LIMITED (JP) 2005-09-01 US disclosed
EP-1555032-A1 MEDICINAL COMPOSITION FOR TREATING ARTERIOSCLEROSIS Sankyo Company, Limited (JP) 2005-07-20 EP disclosed
WO-2005051298-A2 NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS METABASIS THERAPEUTICS, INC. (US) 2005-06-09 WO disclosed
US-20050119314-A1 Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent SANKYO COMPANY, LIMITED (JP) 2005-06-02 US disclosed
EP-1493448-A1 MEDICINAL COMPOSITION COMPRISING ACAT INHIBITOR AND INSULINE RESISTANCE IMPROVING AGENT Sankyo Company, Limited (JP) 2005-01-05 EP disclosed
US-20040198788-A1 Medicinal compositions containing angiotensin II receptor antagonist SANKYO COMPANY, LIMITED (JP) 2004-10-07 US disclosed
EP-1421953-A1 MEDICINAL COMPOSITIONS CONTAINING ANGIOTENSIN II RECEPTOR ANTAGONIST Sankyo Company, Limited (JP) 2004-05-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10925885-B2 Thyromimetics for the treatment of fatty liver diseases TSHR, THRA, FABP1 SOAT1 463/4885
US-20040198788-A1 Medicinal compositions containing angiotensin II receptor antagonist AGTR2, AGTR1, AGT SOAT1 419/4885
US-20060046980-A1 Novel phosphorus-containing thyromimetics PYGL, THRA, THOP1 SOAT1 942/4885
US-20050119314-A1 Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent ACAT2, ACAT1, ACACA SOAT1 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.