Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856660 | 0.81 | L3MBTL1 (0.51) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL8856705 | 0.81 | MAPT (0.59) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL8856398 | 0.79 | KDM4E (0.53) | RAB9ANPC1SMN1; SMN2GAALMNA | |
| SCHEMBL8856573 | 0.79 | KMT2A (0.50) | RAB9AGAAKMT2APOLBKDM4E | |
| SCHEMBL8856628 | 0.79 | MAPT (0.47) | RAB9ANPC1STAT3GAALMNA | |
| SCHEMBL8856488 | 0.78 | SMN1; SMN2 (0.56) | RAB9ANPC1SMN1; SMN2GAALMNA | |
| SCHEMBL8856698 | 0.76 | KDM4E (0.53) | RAB9ANPC1SMN1; SMN2GAALMNA | |
| SCHEMBL8856520 | 0.76 | KMT2A (0.57) | RAB9ANPC1SMN1; SMN2GAALMNA | |
| SCHEMBL8856468 | 0.75 | RAB9A (0.65) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL23084665 | 0.75 | STAT3 (0.72) | RAB9ANPC1STAT3SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648381-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1997-07-15 | — | — | US | disclosed |
| EP-0566446-B1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |