Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | APAF1 | O14727 | 3/20 | 0.57 |
| ▸ | TDP2 | O95551 | 3/20 | 0.57 |
| ▸ | NSD2 | O96028 | 3/20 | 0.57 |
| ▸ | GALK1 | P51570 | 3/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.57 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856546 | 0.86 | MAPT (0.74) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856693 | 0.84 | MAPT (0.57) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856488 | 0.83 | SMN1; SMN2 (0.56) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856503 | 0.83 | SMN1; SMN2 (0.62) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856678 | 0.81 | ALDH1A1 (0.57) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856660 | 0.79 | L3MBTL1 (0.51) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856705 | 0.77 | MAPT (0.59) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856628 | 0.77 | MAPT (0.47) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856927 | 0.76 | KDM4E (0.55) | KMT2AMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL8856508 | 0.76 | RAB9A (0.60) | KMT2AMAPTKDM4EL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648381-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1997-07-15 | — | — | US | disclosed |
| EP-0566446-B1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |