Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | DEPTOR | Q8TB45 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8856505 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8856799 | 0.83 | SENP6 (0.48) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8856796 | 0.83 | SENP6 (0.48) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8856756 | 0.82 | MAPT (0.54) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL8856666 | 0.74 | SENP6 (0.61) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL9004632 | 0.72 | SENP6 (0.55) | SMN1; SMN2MAPTMEN1KMT2ASENP6 | |
| SCHEMBL9004630 | 0.72 | SENP6 (0.55) | SMN1; SMN2MAPTMEN1KMT2ASENP6 | |
| SCHEMBL8857002 | 0.71 | LMNA (0.46) | SMN1; SMN2MAPTMEN1KMT2AKDM4E | |
| SCHEMBL9004636 | 0.71 | CYP1A2 (0.51) | SMN1; SMN2MAPTMEN1KMT2ASENP6 | |
| SCHEMBL8856704 | 0.70 | SENP6 (0.57) | SMN1; SMN2MAPTKMT2AKDM4ESENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648381-A | Derivatives of indan-1,3-dione and indan-1,2,3-trione, methods of preparing them and therapeutic use thereof | INNOTHERA (FR) | 1997-07-15 | — | — | US | disclosed |
| EP-0566446-B1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA LAB SA (FR) | 1996-02-07 | — | — | EP | disclosed |
| EP-0566446-A1 | Derivatives of indane-1,3-dione and indane-1,2,3-trione, processes for their preparation and their application in therapy | INNOTHERA (FR) | 1993-10-20 | — | — | EP | disclosed |
| WO-1993020046-A1 | INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS | INNOTHERA (FR) | 1993-10-14 | — | — | WO | disclosed |