Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858363 | 1.00 | DRD2 (0.37) | DRD2DRD4DRD3KDM1AHTR1A | |
| Hydrochloric Acid SCHEMBL8858358 | 0.99 | HTR1A (0.38) | DRD2DRD4DRD3KDM1AHTR1A | |
| Hydrochloric Acid SCHEMBL8858356 | 0.99 | HTR1A (0.38) | DRD2DRD4DRD3KDM1AHTR1A | |
| SCHEMBL8858344 | 0.86 | DRD2 (0.48) | DRD2DRD4DRD3HTR1AKDM4E | |
| SCHEMBL8858342 | 0.86 | DRD2 (0.48) | DRD2DRD4DRD3HTR1AKDM4E | |
| SCHEMBL8790895 | 0.85 | DRD2 (0.44) | DRD2DRD4DRD3HTR1AKDM4E | |
| SCHEMBL8790889 | 0.85 | DRD2 (0.44) | DRD2DRD4DRD3HTR1AKDM4E | |
| Hydrochloric Acid SCHEMBL8858362 | 0.85 | DRD2 (0.43) | DRD2DRD4DRD3HTR1AKDM4E | |
| Hydrochloric Acid SCHEMBL8858366 | 0.85 | DRD2 (0.43) | DRD2DRD4DRD3HTR1AKDM4E | |
| SCHEMBL8858371 | 0.81 | KDM4E (0.39) | DRD2DRD4DRD3HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665722-A | Benzofuran derivatives as D4 receptor antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-09-09 | — | — | US | disclosed |