Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 3/20 | 0.37 |
| ▸ | DRD3 | P35462 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858371 | 1.00 | KDM4E (0.39) | KDM4ESMN1; SMN2HTR1ASIGMAR1CYP19A1 | |
| SCHEMBL8858342 | 0.85 | DRD2 (0.48) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8858344 | 0.85 | DRD2 (0.48) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8858349 | 0.84 | MAOA (0.45) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8791055 | 0.84 | MAOA (0.45) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8790895 | 0.83 | DRD2 (0.44) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8790889 | 0.83 | DRD2 (0.44) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL8858362 | 0.82 | DRD2 (0.43) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL8858366 | 0.82 | DRD2 (0.43) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 | |
| SCHEMBL8858363 | 0.81 | DRD2 (0.37) | KDM4ESMN1; SMN2HTR1ASIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665722-A | Benzofuran derivatives as D4 receptor antagonists | MERCK, SHARP & DOHME, LTD. (GB) | 1997-09-09 | — | — | US | disclosed |