Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3328982 | 0.84 | MTNR1A (0.59) | MTNR1AMTNR1B | |
| SCHEMBL27853930 | 0.83 | ALDH1A1 (0.43) | ALDH1A1MAPTGAALMNACYP1A2 | |
| SCHEMBL31724327 | 0.80 | KMT2A (0.44) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL6801211 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTGAALMNACYP1A2 | |
| SCHEMBL16466618 | 0.80 | KMT2A (0.44) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL28847197 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1MAPK1HSD17B10 | |
| SCHEMBL1274082 | 0.78 | KMT2A (0.43) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL8721957 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPTGAALMNACYP1A2 | |
| SCHEMBL17465785 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL16811757 | 0.78 | CASP1 (0.49) | ALDH1A1KMT2AMEN1CASP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616614-A | USEFUL IN TREATMENT OF DISORDERS LINKED TO ABNORMAL MELATONIN ACTIVITY | ADIR ET COMPAGNIE (FR) | 1997-04-01 | — | — | US | disclosed |
| EP-0562956-B1 | Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-09-27 | — | — | EP | disclosed |
| US-5420158-A | Melatonin activity | ADIR ET COMPAGNIE (FR) | 1995-05-30 | — | — | US | disclosed |
| EP-0562956-A1 | Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-09-29 | — | — | EP | disclosed |