Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PNLIP | P16233 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590564 | 1.00 | LMNA (0.52) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL8859505 | 0.93 | LMNA (0.52) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL8859511 | 0.93 | LMNA (0.52) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL8933137 | 0.91 | ALDH1A1 (0.50) | LMNAALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL9068191 | 0.89 | LMNA (0.56) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9068185 | 0.89 | LMNA (0.56) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9067641 | 0.87 | LMNA (0.53) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL9068354 | 0.87 | LMNA (0.53) | LMNAALDH1A1HPGDTDP1SMN1; SMN2 | |
| SCHEMBL5168455 | 0.86 | ALDH1A1 (0.53) | LMNAALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL5168461 | 0.86 | ALDH1A1 (0.53) | LMNAALDH1A1HPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670504-A | 2,6-diaryl pyridazinones with immunosuppressant activity | MERCK & CO. INC. (US) | 1997-09-23 | — | — | US | disclosed |
| WO-1996025936-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |