Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | AHR | P35869 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413913 | 0.85 | NPC1 (0.55) | MKNK1MKNK2NPC1RAB9ANR1I2 | |
| SCHEMBL30683712 | 0.83 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2NPY5RKMT2A | |
| SCHEMBL12906820 | 0.83 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2MAPTNPY5R | |
| SCHEMBL28775719 | 0.80 | SMN1; SMN2 (0.39) | MKNK1MKNK2NPC1RAB9ANR1I2 | |
| SCHEMBL4557695 | 0.80 | DYRK1A (0.60) | NPC1RAB9ASMN1; SMN2MAPTNPY5R | |
| SCHEMBL8369776 | 0.80 | NPC1 (0.57) | MKNK1MKNK2NPC1RAB9ANR1I2 | |
| SCHEMBL30683705 | 0.78 | DYRK1A (0.58) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL27386699 | 0.78 | IKBKB (0.47) | MAP4K4 | |
| SCHEMBL5016810 | 0.76 | NPSR1 (0.63) | NPC1RAB9ANR1I2AHRSMN1; SMN2 | |
| SCHEMBL7858380 | 0.75 | RAB9A (0.49) | MKNK1MKNK2NPC1RAB9ANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997011704-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR USE IN VETERINARY THERAPIES AS ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-04-03 | — | — | WO | disclosed |