Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 3/20 | 0.34 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640163 | 0.90 | KMT2A (0.40) | KMT2AANPEPLNPEPCYP1A2HIF1A | |
| SCHEMBL13818365 | 0.84 | KMT2A (0.42) | KMT2AANPEPMMP1MMP13BRD4 | |
| SCHEMBL4508220 | 0.81 | ALDH1A1 (0.39) | KMT2ACYP1A2PPM1BPTPN1PPP1CC | |
| SCHEMBL13640202 | 0.81 | KMT2A (0.42) | KMT2AALOX12NPSR1 | |
| SCHEMBL13640173 | 0.78 | KMT2A (0.49) | KMT2AMMP1MMP13ALOX12NPSR1 | |
| SCHEMBL10331846 | 0.77 | ANPEP (0.36) | KMT2AANPEPLNPEPCYP1A2HIF1A | |
| SCHEMBL23736270 | 0.74 | KMT2A (0.32) | KMT2A | |
| SCHEMBL23736283 | 0.73 | KMT2A (0.31) | KMT2A | |
| Hydrochloric Acid SCHEMBL8801345 | 0.73 | POLB (0.35) | KMT2ACYP1A2BACE1 | |
| SCHEMBL15727225 | 0.72 | CTSD (0.32) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272617-A1 | SUBSTITUTED PHENYLALANINE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-09-22 | — | — | US | disclosed |
| EP-3049390-A1 | SUBSTITUTED PHENYLALANINE DERIVATIVES | Bayer Pharma Aktiengesellschaft (DE) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015044163-A1 | SUBSTITUTED PHENYLALANINE DERIVATIVES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-04-02 | — | — | WO | disclosed |
| US-5637768-A | ADDING WET PENICILLIN ACYLASE TO A SOLUTION OF 6-FLUOROMETHYL-3-(PHENYLACETYL)-AMINO-2-PIPERIDONE, RECOVERING THE DEACETYLATED PRODUCT, ADDING ACID; TREATMENT OF ALZHEIMER*S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0682515-A1 | USE OF INHIBITORS OF ORNITHINE AMINOTRANSFERASE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| WO-1994017795-A1 | USE OF INHIBITORS OF ORNITHINE AMINOTRANSFERASE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272617-A1 | SUBSTITUTED PHENYLALANINE DERIVATIVES | PAH, PEPD, AADAT | KMT2A 1451/4885ANPEP 26/4885LNPEP 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.