Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8862120 | 0.95 | MAPT (0.47) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9429436 | 0.90 | FFAR1 (0.49) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9367587 | 0.84 | MAPT (0.46) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9497982 | 0.81 | MAPT (0.44) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9334200 | 0.80 | APP (0.48) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9367547 | 0.80 | CYP3A4 (0.47) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9333395 | 0.79 | APP (0.52) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8862086 | 0.77 | L3MBTL1 (0.48) | MAPTALDH1A1CYP3A4MAPK1 | |
| SCHEMBL8862041 | 0.77 | L3MBTL1 (0.48) | MAPTALDH1A1CYP3A4MAPK1 | |
| SCHEMBL13939985 | 0.76 | ALDH1A1 (0.43) | MAPTALDH1A1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656636-A | TREATING PSORIASIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5633258-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-27 | — | — | US | disclosed |
| US-5631262-A | Pyridine compounds for treating leukotriene-related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |