Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CD44 | P16070 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8631068 | 0.73 | PDGFRA (0.46) | MEN1KMT2A | |
| SCHEMBL8633263 | 0.73 | SMO (0.48) | MEN1KMT2AHTR7ALDH1A1MAPK1 | |
| SCHEMBL8299446 | 0.71 | ADRA1D (0.48) | KMT2AHTR1ADRD2HTR2AHTR7 | |
| SCHEMBL8797687 | 0.71 | KDM4E (0.49) | MEN1KMT2AHTR1ADRD2HTR2A | |
| SCHEMBL1574406 | 0.70 | HPGD (0.50) | MEN1KMT2ARAB9AALDH1A1NOTUM | |
| SCHEMBL8303856 | 0.67 | PDGFRA (0.47) | ALDH1A1TSHRNOTUM | |
| SCHEMBL9393050 | 0.67 | ALDH1A1 (0.45) | MEN1KMT2AHTR1AHTR2AHTR7 | |
| SCHEMBL1719867 | 0.67 | KDM4E (0.61) | MEN1KMT2ATNFRAB9ANOD2 | |
| SCHEMBL30324527 | 0.66 | HDAC1 (0.51) | MEN1KMT2ATNFRAB9ANOD2 | |
| SCHEMBL8872939 | 0.65 | ADRA1D (0.60) | HTR1ADRD2HTR2AHTR7DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |