Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797687 | 0.81 | KDM4E (0.49) | SMOMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL9393050 | 0.77 | ALDH1A1 (0.45) | SMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL8629937 | 0.75 | MAPT (0.53) | SMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL8864058 | 0.73 | MEN1 (0.44) | MEN1KMT2AALDH1A1MAPK1HTR7 | |
| SCHEMBL8631068 | 0.71 | PDGFRA (0.46) | MEN1KMT2AKDM4E | |
| SCHEMBL28313258 | 0.70 | MAPT (0.68) | SMOMEN1KMT2AMAPTL3MBTL1 | |
| Oxalic Acid SCHEMBL10640941 | 0.67 | KDM4E (0.49) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL8630130 | 0.67 | MAPT (0.47) | SMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL20291632 | 0.66 | KDM4E (0.58) | SMOMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL8303856 | 0.65 | PDGFRA (0.47) | LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |
| EP-0689539-B1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | EP | disclosed |
| WO-1994021630-A1 | ANTIPSYCHOTIC INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |