SCHEMBL8864844

SCHEMBL8864844

O=C(O)/C(=C/c1ccc(Oc2ccccc2)cc1)CBr

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
NPC1 O15118 3/20 0.44
RAB9A P51151 3/20 0.44
ALDH1A1 P00352 3/20 0.44
SRD5A2 P31213 3/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
LMNA P02545 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ERCC5 P28715 1/20 0.44
FEN1 P39748 1/20 0.44
FFAR1 O14842 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
PARP10 Q53GL7 1/20 0.42
HTT P42858 1/20 0.42
LTA4H P09960 2/20 0.41
AKR1C3 P42330 1/20 0.41
TLR4 O00206 1/20 0.41
TLR2 O60603 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8864851 1.00 CYP3A4 (0.47) CYP3A4CYP2C9NPC1RAB9AALDH1A1
SCHEMBL781849 0.84 CYP3A4 (0.63) CYP3A4CYP2C9NPC1RAB9AALDH1A1
SCHEMBL8041928 0.84 CYP3A4 (0.63) CYP3A4CYP2C9NPC1RAB9AALDH1A1
SCHEMBL4327979 0.84 CYP3A4 (0.63) CYP3A4CYP2C9NPC1RAB9AALDH1A1
SCHEMBL8865604 0.82 GSK3B (0.50) CYP3A4NPC1RAB9AALDH1A1LMNA
SCHEMBL8865614 0.82 GSK3B (0.50) CYP3A4NPC1RAB9AALDH1A1LMNA
SCHEMBL8865069 0.81 TP53 (0.59) CYP3A4CYP2C9MEN1KMT2ALMNA
SCHEMBL8865055 0.81 TP53 (0.59) CYP3A4CYP2C9MEN1KMT2ALMNA
SCHEMBL8865503 0.79 NPC1 (0.48) NPC1RAB9AALDH1A1KMT2APARP10
SCHEMBL8865510 0.79 NPC1 (0.48) NPC1RAB9AALDH1A1KMT2APARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5663342-A GLUCOSIDASE INHIBITORS, ANTIVIRAL, ANTI-HIV G. D. SEARLE & CO. (US) 1997-09-02 US disclosed
US-5646313-A PREPARING ENKEPHALINASE INHIBITORS SOCIETE CIVILE BIOPROJET (FR) 1997-07-08 US disclosed
US-5612371-A ENZYME INHIBITORS SOCIETE CIVILE BIOPROJECT (FR) 1997-03-18 US disclosed