Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865462 | 0.88 | PARP1 (0.43) | ADRA1AADRA2ACA1CA2 | |
| SCHEMBL7097683 | 0.86 | ADRA1A (0.40) | ADRA1AADRA2ACA1CA2CYP11B2 | |
| SCHEMBL8865796 | 0.85 | ADRA2A (0.49) | ADRA1AADRA2AADRA1DADRA1B | |
| SCHEMBL8865945 | 0.84 | HTR1A (0.41) | HTR1A | |
| SCHEMBL7608212 | 0.82 | ADRA2A (0.40) | ADRA1AADRA2AADRA1DADRA1B | |
| SCHEMBL8865410 | 0.82 | ADRA2A (0.59) | ADRA2ASIGMAR1 | |
| SCHEMBL7103607 | 0.82 | ADRA2A (0.59) | ADRA1AADRA2AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL8865395 | 0.81 | ADRA2A (0.57) | ADRA2ASIGMAR1 | |
| SCHEMBL7101744 | 0.80 | ADRA2A (0.48) | ADRA1AADRA2ACA1CA2 | |
| SCHEMBL8866074 | 0.80 | ADRA1A (0.45) | ADRA1AADRA2ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | claimed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | claimed |
| US-5658938-A | HYPOTENSIVE AGENT, ANTIISCHMIC AGENTS | U C B S.A. (BE) | 1997-08-19 | — | — | US | disclosed |
| EP-0717037-A1 | Substituted 1H-imidazoles having alpha 2-agonistic and alpha 1-antagonistic activity | U C B, S.A. (BE) | 1996-06-19 | — | — | EP | disclosed |