Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methamphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.70 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methamphetamine SCHEMBL28616142 | 0.98 | TAAR1 (0.72) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL25290133 | 0.98 | TAAR1 (0.72) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL28616144 | 0.98 | TAAR1 (0.72) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL25290134 | 0.98 | TAAR1 (0.72) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL27703114 | 0.87 | SIGMAR1 (0.70) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL7036433 | 0.86 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL29112697 | 0.86 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL7036430 | 0.86 | SIGMAR1 (0.81) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42098 | 0.86 | SIGMAR1 (0.95) | TAAR1SIGMAR1SLC18A2NPC1RAB9A | |
| Methamphetamine SCHEMBL42100 | 0.86 | SIGMAR1 (0.95) | TAAR1SIGMAR1SLC18A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |