Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNG | P07510 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CHRND | Q07001 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457735 | 0.74 | LPO (0.39) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL10005373 | 0.70 | ALDH1A1 (0.74) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL4246356 | 0.70 | ALDH1A1 (0.49) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL4132663 | 0.69 | ALDH1A1 (0.61) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL17544664 | 0.69 | RAB9A (0.44) | ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL329177 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL28276561 | 0.69 | ALDH1A1 (1.00) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL12424656 | 0.68 | ALDH1A1 (0.59) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL2936161 | 0.67 | ALDH1A1 (0.69) | ALDH1A1KMT2APOLBTLR8LMNA | |
| SCHEMBL9935809 | 0.67 | ALDH1A1 (0.63) | ALDH1A1KMT2APOLBTLR8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5604224-A | NEURODEGENERATIVE DISORDERS | STERLING WINTHROP INC. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5569655-A | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1996-10-29 | — | — | US | disclosed |
| EP-0647641-A1 | Substituted heterocyclylisoquinolinium salts and compositions and methods of usethereof | STERLING WINTHROP INC. (US) | 1995-04-12 | — | — | EP | disclosed |