Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867607 | 0.83 | L3MBTL1 (0.45) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL31283268 | 0.83 | TSHR (0.39) | L3MBTL1TSHRALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6208321 | 0.73 | L3MBTL1 (0.40) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6824028 | 0.72 | ALDH1A1 (0.50) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL24606816 | 0.69 | TSHR (0.50) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL9373811 | 0.69 | L3MBTL1 (0.53) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5986980 | 0.68 | TSHR (0.53) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL895343 | 0.68 | L3MBTL1 (0.55) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL505705 | 0.67 | L3MBTL1 (0.51) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3956031 | 0.67 | JAK2 (0.37) | L3MBTL1TSHRKMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0490901-A1 | NOVEL SPIROFURANE DERIVATIVES | Astra Aktiebolag (SE) | 1992-06-24 | — | — | EP | disclosed |
| EP-0490901-A4 | NOVEL SPIROFURANE DERIVATIVES. | FISONS CORP (US) | 1992-04-13 | — | — | EP | disclosed |
| WO-1990015804-A1 | NOVEL SPIROFURANE DERIVATIVES | FISONS CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |