Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693197 | 0.81 | USP2 (0.40) | L3MBTL1TSHRSMN1; SMN2 | |
| SCHEMBL3956031 | 0.79 | JAK2 (0.37) | L3MBTL1TSHRHRH2HRH1CYP2D6 | |
| SCHEMBL3955003 | 0.78 | CYP2D6 (0.39) | L3MBTL1TSHRHRH2HRH1GAA | |
| SCHEMBL8867607 | 0.77 | L3MBTL1 (0.45) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL7096473 | 0.74 | TLR8 (0.35) | L3MBTL1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8866898 | 0.73 | L3MBTL1 (0.41) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6824028 | 0.71 | ALDH1A1 (0.50) | L3MBTL1TSHRALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3663186 | 0.70 | CYP2D6 (0.42) | L3MBTL1TSHRALDH1A1HRH2HRH1 | |
| SCHEMBL4074787 | 0.70 | RAB9A (0.41) | L3MBTL1ALDH1A1HRH2HRH1CYP2D6 | |
| SCHEMBL26705603 | 0.69 | RAB9A (0.40) | L3MBTL1TSHRALDH1A1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603901-A1 | TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078750-A1 | TETRAHYDROPYRAN COMPOUNDS AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2004-09-16 | — | — | WO | disclosed |