Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866917 | 0.91 | ITGB3 (0.49) | ITGB3ITGA2BSUV39H2CHRM4 | |
| SCHEMBL8866386 | 0.90 | SUV39H2 (0.39) | ITGB3ITGA2BSUV39H2CHRM4 | |
| SCHEMBL8866816 | 0.85 | MKNK1 (0.42) | SUV39H2CHRM4 | |
| SCHEMBL8865883 | 0.83 | PRSS1 (0.53) | ITGB3ITGA2BSUV39H2F10PRSS1 | |
| Water SCHEMBL8867564 | 0.83 | PRSS1 (0.52) | ITGB3ITGA2BSUV39H2F10PRSS1 | |
| SCHEMBL8868200 | 0.83 | ITGB3 (0.49) | ITGB3ITGA2BSUV39H2CHRM4F10 | |
| SCHEMBL9235366 | 0.81 | SUV39H2 (0.44) | ITGB3ITGA2BSUV39H2CHRM4F10 | |
| SCHEMBL8866426 | 0.81 | SUV39H2 (0.42) | ITGB3ITGA2BSUV39H2CHRM4 | |
| SCHEMBL9189037 | 0.79 | ITGB3 (0.54) | ITGB3ITGA2BALOX15KDM1A | |
| SCHEMBL8866329 | 0.78 | SUV39H2 (0.47) | SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614531-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0668278-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1995-08-23 | — | — | EP | disclosed |