Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866999 | 0.91 | KCNA5 (0.44) | MKNK1MKNK2ALDH1A3KCNA5EGLN2 | |
| SCHEMBL8865946 | 0.87 | CETP (0.40) | MKNK1MKNK2KCNA5EGLN2HRH3 | |
| SCHEMBL8866386 | 0.85 | SUV39H2 (0.39) | ALDH1A1CHRM4SUV39H2 | |
| SCHEMBL8867044 | 0.85 | ITGB3 (0.48) | CHRM4SUV39H2 | |
| SCHEMBL8866335 | 0.83 | MKNK1 (0.43) | MKNK1MKNK2ALDH1A3EGLN2SUV39H2 | |
| SCHEMBL8866854 | 0.83 | MKNK1 (0.40) | MKNK1MKNK2ALDH1A3EGLN2PRKAA2 | |
| SCHEMBL8865989 | 0.82 | SUV39H2 (0.41) | MKNK1MKNK2KCNA5EGLN2HRH3 | |
| SCHEMBL8866150 | 0.80 | ALDH1A3 (0.52) | ALDH1A3EGLN2ALDH1A1SUV39H2 | |
| Bromide SCHEMBL8866486 | 0.79 | ALDH1A3 (0.51) | ALDH1A3EGLN2ALDH1A1SUV39H2 | |
| SCHEMBL8866770 | 0.77 | EGLN1 (0.47) | ALDH1A3EGLN2ALDH1A1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614531-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-03-25 | — | — | US | disclosed |
| EP-0668278-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1995-08-23 | — | — | EP | disclosed |