Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8867155 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL8867149 | 1.00 | — | — | |
| SCHEMBL9388416 | 0.93 | — | — | |
| SCHEMBL9388421 | 0.93 | — | — | |
| Maleic Acid SCHEMBL9698746 | 0.85 | — | — | |
| Maleic Acid SCHEMBL8867962 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL8866614 | 0.85 | — | — | |
| Maleic Acid SCHEMBL8866609 | 0.85 | — | — | |
| Maleic Acid SCHEMBL8866602 | 0.85 | — | — | |
| Fumaric Acid SCHEMBL8866997 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | claimed |