Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8866982 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL8866989 | 1.00 | — | — | |
| Maleic Acid SCHEMBL9698742 | 0.96 | — | — | |
| Maleic Acid SCHEMBL8867958 | 0.96 | — | — | |
| Fumaric Acid SCHEMBL8867969 | 0.96 | — | — | |
| SCHEMBL1326631 | 0.89 | — | — | |
| Maleic Acid SCHEMBL9698746 | 0.86 | — | — | |
| Maleic Acid SCHEMBL8867962 | 0.86 | — | — | |
| Methoxymethane SCHEMBL8867828 | 0.85 | — | — | |
| Methoxymethane SCHEMBL8866956 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594000-A | THAT STIMULATE CENTRAL MUSCARINIC ACETYLCHOLINE RECEPTORS, ANALGESICS, NERVOUS SYSTEM DISORDERS, MENTAL ILLNESS | ASTRA AB (SE) | 1997-01-14 | — | — | US | disclosed |
| WO-1994000456-A1 | SPIROFURANE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS | FISONS CORPORATION (US) | 1994-01-06 | — | — | WO | disclosed |
| EP-0491562-A1 | Novel spirofurane derivatives | FISONS CORPORATION (US) | 1992-06-24 | — | — | EP | disclosed |