Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | CTRC | Q99895 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868135 | 0.84 | TOP2A (0.38) | HSD17B3TSHRTOP2ATOP2BALDH1A1 | |
| SCHEMBL30144051 | 0.61 | POLB (0.51) | THRBHSD17B3TSHRPOLBALDH1A1 | |
| SCHEMBL27691202 | 0.61 | AKR1A1 (0.48) | TSHRTP53ALDH1A1 | |
| SCHEMBL19971597 | 0.60 | TOP2A (0.48) | TOP2ATOP2B | |
| SCHEMBL6807700 | 0.59 | MEN1 (0.50) | HSD17B3TSHRTP53POLBALDH1A1 | |
| Diphenylmethane SCHEMBL1064958 | 0.59 | MAOA (0.74) | ALDH1A1L3MBTL1 | |
| SCHEMBL11494803 | 0.58 | PDE3B (0.43) | ALDH1A1NR1H2CTRC | |
| SCHEMBL17933754 | 0.58 | HSD17B3 (0.51) | HSD17B3TSHRALDH1A1L3MBTL1 | |
| SCHEMBL6836937 | 0.57 | MAOA (0.34) | ALDH1A1 | |
| SCHEMBL2398512 | 0.57 | CYP11B1 (0.77) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677296-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | G.D. SEARLE & CO. (US) | 1997-10-14 | — | — | US | disclosed |
| US-5488046-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1996-01-30 | — | — | US | disclosed |