Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYNU | Q16719 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CTSK | P43235 | 9/20 | 0.57 |
| ▸ | CTSS | P25774 | 3/20 | 0.54 |
| ▸ | CTSL | P07711 | 2/20 | 0.54 |
| ▸ | CTSB | P07858 | 2/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.52 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3187144 | 0.94 | CTSK (0.57) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL3177275 | 0.92 | CTSK (0.57) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL14609392 | 0.87 | CTSK (0.74) | KYNUCTSKCTSSCTSLCTSB | |
| SCHEMBL12876847 | 0.87 | KYNU (0.62) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL13611959 | 0.87 | CTSK (0.74) | KYNUCTSKCTSSCTSLCTSB | |
| SCHEMBL3978105 | 0.87 | CTSK (0.74) | KYNUCTSKCTSSCTSLCTSB | |
| SCHEMBL13886795 | 0.86 | CTSS (0.54) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL3331851 | 0.86 | KYNU (0.60) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL3331858 | 0.86 | KYNU (0.60) | KYNUALDH1A1ALOX15CTSKCTSS | |
| SCHEMBL30913958 | 0.86 | KYNU (0.60) | KYNUALDH1A1ALOX15CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670684-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| US-5576435-A | Process and intermediates for the preparation of excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5470978-A | Process and intermediates for the preparation of excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0599518-A1 | Process and intermediates for the preparation of excitatory amino acide receptor antagonists | ELI LILLY AND COMPANY (US) | 1994-06-01 | — | — | EP | disclosed |