Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867157 | 0.83 | LMNA (0.51) | ALDH1A1HTTSMN1; SMN2MAPTNPC1 | |
| SCHEMBL1140385 | 0.81 | MLYCD (0.53) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL28395302 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL30164408 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL20264485 | 0.77 | HTT (0.46) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL12534115 | 0.76 | HSP90AA1 (0.58) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL2537515 | 0.74 | ALDH1A1 (0.71) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL3458382 | 0.74 | ALDH1A1 (0.53) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL6560736 | 0.74 | ALDH1A1 (0.49) | ALDH1A1HTTHSP90AA1PDK1PDK2 | |
| SCHEMBL12652664 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HTTHSP90AA1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614637-A | Process for preparing 1,3-dialkyl-5-hydroxyoxindoles and the ether derivatives thereof | BOEHRINGER INGELHEIM KG (DE) | 1997-03-25 | — | — | US | disclosed |