Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8868726 | 0.92 | P4HTM (0.50) | P4HTMEGFRPOLBTDP1KMT2A | |
| SCHEMBL8868717 | 0.92 | P4HTM (0.48) | P4HTMEGFRPOLBTDP1MEN1 | |
| SCHEMBL8869147 | 0.92 | P4HTM (0.46) | P4HTMEGFRPOLBTDP1MEN1 | |
| SCHEMBL8869167 | 0.90 | P4HTM (0.54) | P4HTMEGFRMEN1KMT2AFLT1 | |
| SCHEMBL8869141 | 0.90 | P4HTM (0.45) | P4HTMEGFRPOLBTDP1MEN1 | |
| SCHEMBL8870231 | 0.90 | CA2 (0.47) | P4HTMEGFRPOLBTDP1MEN1 | |
| SCHEMBL8869158 | 0.89 | P4HTM (0.49) | P4HTMCA12CA9CA2 | |
| SCHEMBL8868602 | 0.88 | NPC1 (0.51) | P4HTMPOLBMEN1KMT2ACA9 | |
| SCHEMBL8868067 | 0.88 | HPGD (0.44) | P4HTMEGFRPOLBTDP1MEN1 | |
| SCHEMBL9137563 | 0.88 | P4HTM (0.52) | P4HTMEGFRFLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |