Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8867391 | 0.77 | DHODH (0.51) | PSMB5KMT2ASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL9411557 | 0.76 | KDM4E (0.44) | PSMB5PDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL8867753 | 0.75 | TLR7 (0.42) | PSMB5PDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL1398173 | 0.71 | CYP1A2 (0.46) | PSMB5KMT2ASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL22288210 | 0.71 | PSMB5 (0.64) | PSMB5PDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL23262666 | 0.71 | TRIM24 (0.42) | KMT2AKDM4ETDP1L3MBTL1HTT | |
| SCHEMBL29953935 | 0.71 | ERN1 (0.47) | KMT2AKDM4ETDP1L3MBTL1MEN1 | |
| SCHEMBL29923876 | 0.70 | KDM4E (0.43) | PSMB5PDGFRBPDGFRAKDM4ETLR7 | |
| SCHEMBL24916333 | 0.70 | KDM4E (0.43) | PSMB5PDGFRBPDGFRAKDM4ETLR7 | |
| SCHEMBL3088721 | 0.69 | PSMB5 (0.61) | PSMB5PDGFRBPDGFRAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629320-A | INOTROPIC AGENTS, HYPOTENSIVE AGENTS, OTHER CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-05-13 | — | — | US | disclosed |
| US-5550245-A | INTERMEDIATES FOR AGENTS USED IN THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-27 | — | — | US | disclosed |
| US-5504210-A | TREATMENT FOR CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |
| EP-0627427-A1 | 3-Quinolyl substituted dihydropyridines, process for their preparation and their use in drugs | BAYER AG (DE) | 1994-12-07 | — | — | EP | disclosed |