Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.46 |
| ▸ | CAMKK1 | Q8N5S9 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9411557 | 0.81 | KDM4E (0.44) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL11819344 | 0.77 | ACMSD (0.56) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL11820122 | 0.77 | ACMSD (0.56) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL11816217 | 0.77 | ACMSD (0.56) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL8867889 | 0.77 | PSMB5 (0.45) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL8867753 | 0.77 | TLR7 (0.42) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL11813461 | 0.76 | ACMSD (0.51) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL9766384 | 0.76 | ACMSD (0.57) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL11815948 | 0.76 | ACMSD (0.55) | DHODHKDM4EGLAHTTKMT2A | |
| SCHEMBL28140597 | 0.75 | DHODH (0.47) | DHODHKMT2ASMN1; SMN2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629320-A | INOTROPIC AGENTS, HYPOTENSIVE AGENTS, OTHER CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-05-13 | — | — | US | disclosed |
| US-5550245-A | INTERMEDIATES FOR AGENTS USED IN THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-08-27 | — | — | US | disclosed |
| US-5504210-A | TREATMENT FOR CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-02 | — | — | US | disclosed |
| CN-1100419-A | 3-quinolyl-substituted dihydropyridines, process for their preparation and their use in medicaments | BAYER AG (DE) | 1995-03-22 | — | — | CN | disclosed |
| EP-0627427-A1 | 3-Quinolyl substituted dihydropyridines, process for their preparation and their use in drugs | BAYER AG (DE) | 1994-12-07 | — | — | EP | disclosed |