Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869631 | 0.97 | P4HTM (0.53) | P4HTMEGFRCA2FLT1FLT4 | |
| SCHEMBL8869667 | 0.94 | P4HTM (0.53) | P4HTMEGFRCA2FLT1FLT4 | |
| SCHEMBL8868196 | 0.94 | P4HTM (0.53) | P4HTMEGFRCA2FLT1FLT4 | |
| SCHEMBL8867931 | 0.93 | HPGD (0.51) | P4HTMEGFRHPGDNPC1RAB9A | |
| SCHEMBL8869333 | 0.92 | P4HTM (0.48) | P4HTMEGFRCA2FLT1FLT4 | |
| SCHEMBL8869755 | 0.92 | P4HTM (0.54) | P4HTMEGFRFLT1FLT4KDR | |
| SCHEMBL8868438 | 0.91 | P4HTM (0.48) | P4HTMEGFRCA2FLT1FLT4 | |
| SCHEMBL9138259 | 0.91 | P4HTM (0.61) | P4HTMEGFRCA2HPGDNPC1 | |
| SCHEMBL8869712 | 0.90 | CA2 (0.50) | P4HTMEGFRCA2HPGDNPC1 | |
| SCHEMBL8869447 | 0.90 | P4HTM (0.49) | P4HTMEGFRCA2FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607954-A | Sulfonamido- and sulfonamidocarbonylpyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-04 | — | — | US | disclosed |